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1. | 引間知広 (Tomohiro HIKIMA)
九州工業大学におけるマイクロニードルの研究開発. (Research and development of microneedle array at Kyushu Institute of Technology) 三島光産技報, 41: 10-16, 2020. (in Japanese) |
2. | 引間知広, 井上茉莉 (Tomohiro HIKIMA, Mari INOUE)
経強膜イオントフォレシスによる後眼部への高分子化合物の送達促進. (Trans-scleral iontophoresis delivery of high molecular weight compound into the posterior segment of the eye) あたらしい眼科 (J Eye), 36(9): 1194-1197, 2019. (in Japanese) |
1. | 引間知広, 木下真梨子 (Tomohiro HIKIMA, Mariko KINOSHITA)
乾燥肌に対するビート由来グルコシルセラミド含有物の効果. (Effect of glucosylceramide-containing beet extract on dry skin) Fragrance Journal, 7月号: 82-85, 2019. (in Japanese) |
1. | Tomohiro HIKIMA, Masatoshi KAWAKAMI, Kakuji TOJO.
Characterization of an in vitro penetration system for ocular iontophoresis. J Chem Eng Japan, 51(5): 418-422, 2018. https://doi.org/10.1252/jcej.17we084 |
2. | Tomohiro HIKIMA and Kakuji TOJO.
Combined Use of Iontophoresis and Other Physical Methods. In Percutaneous Penetration Enhancers: Physical Methods in Penetration Enhancement. Nina Dragicevic and Howard Maibach (Eds), Springer, May, 2017. https://doi.org/10.1007/978-3-662-53273-7_22 |
1. | Asako INOUE, Tomohiro HIKIMA, Suguru TANIGUCHI, Takeru NOSE, Iori MAEDA.
Investigation of water-soluble elastin as a multifunctional cosmetic material: Moisturizing and whitening effects. J Cosmet Sci, 68(1): 11-24, 2017. https://pubmed.ncbi.nlm.nih.gov/29465378/ |
1. | 引間知広.
経皮吸収の改善/促進法とマイクロニードル. Fragrance Journal, 1月号: 12-19, 2015. (in Japanese) |
1. | 引間知広.
経皮治療システムの現状と微細加工技術の応用. 三島光産技報, 35: 15-20, 2014. (in Japanese) |
4. | Ryo MOROFUJI, Tomohiro HIKIMA, Kakuji TOJO.
Effect of diffusive direction across the skin on the penetration profile of chemicals in vitro. Biol Pharm Bull, 36(11): 1760-1765, 2013. https://doi.org/10.1248/bpb.b13-00331 |
3. | 引間知広.
経皮吸収に関する研究. Cosme Tech Japan, 3(9): 52-60, 2013. (in Japanese) |
2. | 引間知広
第13章6節 MEMSを利用した薬物送達システムの開発事例 DDS製剤の開発・評価と実用化手法 株式会社技術情報協会, 2013年3月. (in Japanese) |
1. | Tomohiro HIKIMA, Yoshinaga TAMURA, Yukio YAMAWAKI, Masashi YAMAMOTO, Kakuji TOJO.
Skin accumulation and penetration of a hydrophilic compound by a novel gemini surfactant, sodium dilauramidoglutamide lysine. Int J Pharm, 443(1-2): 288-292, 2013. https://doi.org/10.1016/j.ijpharm.2012.12.034 |
1. | Tomohiro HIKIMA, Noriaki KANEDA, Kyouhei MATSUO and Kakuji TOJO.
Prediction of percutaneous absorption in human using three-dimensional human cultured epidermis LabCyte EPI-MODEL. Biol Pharm Bull, 35(3): 362-368, 2012. https://doi.org/10.1248/bpb.35.362 |
2. | 引間知広,東條角治
第4章 1.物理的促進法の最新技術概論 次世代経皮吸収製剤の開発と応用 シーエムシー出版, 2011年7月. (in Japanese) |
1. | 引間知広
第8章 7.試料作成用途として ホットメルト材料および装置、製品の最新技術と使い方ノウハウ 株式会社技術情報協会, 2011年1月. (in Japanese) |
2. | 引間知広,冨永健治.
経皮治療システムにおける透過促進剤. Cosmetic Stage 7月増刊号, 10-13、2010. (in Japanese) |
1. | 引間知広,冨永健治.
経皮治療システムにおける物理的透過促進法 Cosmetic Stage 7月増刊号, 14-18、2010. (in Japanese) |
1. | Tomohiro HIKIMA, Shinya OHSUMI, Kenta SHIROUZU and Kakuji TOJO.
Mechanisms of the synergistic skin penetration by sonophoresis and iontophoresis. Biol Pharm Bull, 32(5): 905-909, 2009. https://doi.org/10.1248/bpb.32.905 |
2. | Kohei SHIRAKAMI, Tomohiro HIKIMA and Kakuji TOJO.
Control of barrier capacity of stratum corneum by microdermabrasion. J Chem Eng Japan, 41(12): 1123-1126, 2008. https://doi.org/10.1252/jcej.08we169 |
1. | Kenta SHIROUZU, Tetsuya NISHIYAMA, Tomohiro HIKIMA, and Kakuji TOJO.
Synergistic effect of sonophoresis and iontophoresis in transdermal drug delivery. J Chem Eng Japan, 41(4): 300-305, 2008. https://doi.org/10.1252/jcej.07we276 |
3. | Kakuji TOJO and Tomohiro HIKIMA.
Bioequivalence of marketed transdermal delivery systems for tulobuterol. Biol Pharm Bull, 30(8): 1576-1579, 2007. https://doi.org/10.1248/bpb.30.1576 |
2. | Tomohiro HIKIMA and Howard I. Maibach
Gender differences of enzymatic activity and distribution of 17b-hydroxysteroid dehydrogenase in human skin in vitro. Skin Pharmacol Physiol, 20(4): 168-174, 2007. https://doi.org/10.1159/000101386 |
1. | 引間知広, 因昭一, 中村昭範, 東條角治.
経皮治療システム用貼付製剤製造装置の開発. 膜, 32(2): 116-119, 2007. (in Japanese) https://doi.org/10.5360/membrane.32.116 |
2. | Tomohiro HIKIMA and Howard I. MAIBACH.
Skin penetration flux and lag-time of steroids across hydrated and dehydrated human skin in vitro. Biol Pharmacol Bull, 29(11): 2270-2273, 2006. https://doi.org/10.1248/bpb.29.2270 |
1. | Takamitsu MIYAGI, Tomohiro HIKIMA, and Kakuji TOJO.
Effect of molecular weight of penetrants on iontophoretic transdermal delivery in vitro. J Chem Eng Japan, 39(3): 360-365, 2006. https://doi,org/10.1252/jcej.39.360 |
1. | Tomohiro Hikima, Kakuji Tojo, and Howard I. Maibach.
Skin metabolism in transdermal therapeutic systems. Skin Pharmacol Physiol, 18(4): 153-159, 2005. https://doi.org/10.1159/000085860 |
1. | Qing Wang, Tomohiro Hikima, Kakuji Tojo.
Skin penetration enhancement by synergistic effect of supersaturated dissolution and chemical enhancers. J Chem Eng Japan, 36(1): 92-97, 2003. https://doi.org/10.1252/jcej.36.92 |
3. | Qing Wang, Tomohiro Hikima, Kakuji Tojo.
Effect of supersaturated dissolution and crystallization on in vitro skin penetration of 17-b-estradiol from acrylic pressure sensitive adhesives. J Chem Eng Japan, 35(8): 771-777, 2002. https://doi.org/10.1252/jcej.35.771 |
2. | Tomohiro Hikima, Kayoko Yamada, Tohru Kimura, Howard I. Maibach, Kakuji Tojo.
Comparison of skin distribution of hydrolytic activity for bioconversion of beta-estradiol 17-acetate between man and several animals in vitro. Eur J Pharm Biopharm, 54(2): 155-160, 2002. https://doi.org/10.1016/S0939-6411(02)00084-X |
1. | 引間知広, 東條角治.
薬物の皮膚透過と皮膚代謝に及ぼす超音波の影響. 超音波テクノ, 14(1): 51-54, 2002. (in Japanese) |
4. | Tomohiro HIKIMA, Yasuo OHNO, Howard I. MAIBACH
Metabolism of prednisolone 21-acetate in hairless mouse skin. Skin Pharmacol Appl Skin Physiol, 14(4): 203-209, 2001. https://doi.org/10.1159/000056348 |
3. | Tomohiro HIKIMA and Howard I. MAIBACH
Distribution of hydrolytic activity catalize the biotransformation of prednisolone 21-acetate in human skin. Skin Pharmacol Appl Skin Physiol, 14(4): 196-202, 2001. https://doi.org/10.1159/000056347 |
2. | 引間知広
経皮治療システムにおける超音波利用 化学工学, 66(3): 184, 2001. (in Japanese) |
1. | 引間知広, 東條角治.
経皮治療システム研究における皮膚モデル. Drug Deliv Syst, 16 (3): 179-181, 2001. (in Japanese) https://doi.org/10.2745/dds.16.179 |
1. | 引間知広, 東條角治.
薬物の皮膚透過および皮膚内代謝活性のヘアレスマウス系統による差異. Drug Deliv Syst, 15 (3): 203-207, 2000.(in Japanese) https://doi.org/10.2745/dds.15.203 |
1. | Tomohiro Hikima, Yoshiaki Hirai, Kakuji Tojo.
Effect of ultrasound application on the skin metabolism of prednisolone 21-acetate. Pharm Res, 15 (11): 1680-1683, 1998. https://doi.org/10.1023/A:1011944209274 |
1. | Tomohiro Hikima, Kakuji Tojo.
Binding of prednisolone and its ester prodrugs in the skin. Pharm Res, 14 (2): 197-202, 1997. https://doi.org/10.1023/A:1012052827872 |
1. | 引間知広, 東條角治.
結合と代謝をともなう薬物の皮膚吸収. 薬剤学, 55: 122-126, 1995.(in Japanese) |
1. | Kakuji Tojo, Kayoko Yamada, Tomohiro Hikima.
Diffusion and metabolism of prednisolone farnesylate in the stripped skin. Pharm Res, 11(3): 393-397, 1994. https://doi.org/10.1023/a:1018960920313 |
1. | 引間知広, 東條角治.
薬物の皮膚代謝におよぼす透過促進剤の影響. Drug Deliv Syst, 8: 291-295, 1993. (in Japanese) https://doi.org/10.2745/dds.8.291 |
2. | 引間知広, 山田佳世子, 山下明泰, 東條角治.
代謝をともなう薬物の皮膚透過. Drug Deliv Syst, 7: 453-457, 1992. (in Japanese) https://doi.org/10.2745/dds.7.453 |
1. | 山下明泰, 引間知広, 大鳥聡, 東條角治.
薬物皮膚透過におよぼす温度の影響-in vitro実験による評価. Therapeutic Research, 13: 3129-3130, 1992. (in Japanese) |