1. |
Tomohiro HIKIMA, Yoshinaga TAMURA, Yukio YAMAWAKI, Masashi YAMAMOTO, Kakuji TOJO. Skin accumulation and penetration of a hydrophilic compound by a novel gemini surfactant, sodium dilauramidoglutamide lysine. Int J Pharm, 443(1-2): 288-292, 2013 |
2. |
東條角治. 仮想患者による経皮薬物吸収の体内動態予測. ファルマシア, 49(5): 380-384, 2013 |
3. |
森大輔, 東條角治. 経皮吸収型製剤の開発状況と今後の展望. 薬局, 64(13): 138-143, 2013 |
1. |
Akinori NAKAMURA, Daisuke MORI, Kakuji TOJO. Evaluation of the predicted time-concentration profile of serum tulobuterol in human after transdermal application, Chem Pharm Bull. 60(3): 300-305, 2012 |
2. |
Tomohiro HIKIMA, Noriaki KANEDA, Kyouhei MATSUO and Kakuji TOJO. Prediction of percutaneous absorption in human using three-dimensional human cultured epidermis LabCyte EPI-MODEL. Biol Pharm Bull, 35(3): 362-368, 2012 |
3. |
東條角治. 経皮吸収システムの薬物動態シミュレータSKIN-CAD. Pharm Tech Japan, 28(7): 131-136, 2012 |
1. |
Kakuji TOJO and Tomohiro HIKIMA. Bioequivalence of Marketed Transdermal Delivery Systems for Tulobuterol. Biol Pharm Bull, 30(8): 1576-1579, 2007 |
2. |
Chiharu KIMURA and Kakuji TOJO. Development of a stick-type transdermal eyelid delivery system of ketotifen fumarate for ophthalmic diseases. Chem Pharm Bull, 55(7): 1002-1005, 2007 |
3. |
Chiharu KIMURA, Toshihiro NAKANISHI and Kakuji TOJO. Skin permeation of ketotifen applied from stick-type formulation. Eur J Pharm Biopharm, 67(2): 420-424, 2007 |
4. |
引間知広, 因昭一, 中村昭範, 東條角治. 経皮治療システム用貼付製剤製造装置の開発. 膜, 32(2): 116-119, 2007. |
5. |
Koji KAWAHARA and Kakuji TOJO. Skin Irritation in Transdermal Drug Delivery Systems: A Strategy for its Reduction. Pharm Res, 24(2): 399-408, 2007 |
1. |
東條角治. 生物機能模倣とDDS開発への応用. 化学工学, 2005. |
2. |
藤本朋子, 東條角治. 眼内DDS製剤の現状と今後の進歩. 月刊薬事11月号, 47(12): 1121-1126, 2005. |
3. |
東條角治, 眼科ドラッグデリバリー研究における薬物動態シミュレータの利用,
臨床眼科, 59 (11): 238-245, 2005 |
4. |
T. Fujimoto, K. Shirakami, and K. Tojo. Effect of microdermabrasion on barrier capacity of stratum corneum. Chem Pharm Bull, 53(8): 1014-1016, 2005. |
5. |
T. Hikima, K. Tojo, and H. I. Maibach. Skin metabolism in transdermal therapeutic systems. Skin Pharmacol Physiol, 18(4): 153-159, 2005. |
1. |
東條角治. 経皮治療システムの最近の進歩. 化学工学, 67 (12): 689-691, 2003. |
2. |
礒脇明治, 大鳥聡, 松尾優美, 東條角治. プレドニゾロン経皮吸収製剤の in-vitro / in-vivo / in-silico 評価. 化学工学論文集, 29 (6): 760-763, 2003. |
3. |
A. Isowaki, A. Ohtori , Y. Matsuo, K. Tojo. Drug delivery to the eye with a transdermal therapeutic system. Biol Pharm Bull, 26 (1): 69-72, 2003. |
4. |
D. Mori. H. Kawamata, K. Tojo. Drug concentration-time profile in the plasma following the dissolution-type transdermal delivery. J Chem Eng Japan, 36 (1): 45-48, 2003. |
5. |
Q. Wang, T. Hikima, K. Tojo. Skin penetration enhancement by synergistic effect of supersaturated dissolution and chemical enhancers. J Chem Eng Japan, 36 (1): 92-97, 2003. |
1. |
Q. Wang, T. Hikima, K.Tojo. Studies on the synergistic enhancement of supersaturated dissolution and enhancer in matrix transdermal drug delivery system. J Chem Eng Japan, 35 (8): 771-777, 2002. |
2. |
森大輔, 東條角治. 電場(Iontophoresis)による薬物皮膚吸収の促進. BME, 16 (7): 8-13, 2002. |
3. |
H. Aoyagi, A. Isowaki, K. Tojo. In Vivo/In Vitro Correlation of Intravitreal Drug Delivery from Biodegradable Polymer Implants. J Chem Eng Japan, 35 (5): 450-455, 2002. |
4. |
H. Kawamata, K. Tojo. Prediction of plasma concentration of GTS-21 in hairless rats following monolithic transdermal delivery. Biol Pharm Bull, 25 (3): 342-345, 2002. |
5. |
T. Hikima, K. Yamada, T. Kimura, H. I. Maibach, K. Tojo. Comparison of skin distribution of hydrolytic activity for bioconversion of beta-estradiol 17-acetate between man and several animals in vitro. Eur J Pharm Biopharm, 54 (2): 155-160, 2002. |
6. |
引間知広, 東條角治. 薬物の皮膚透過と皮膚代謝に及ぼす超音波の影響. 超音波テクノ, 14 (1): 51-54, 2002. |
1. |
A.-R. C. Lee, K. Tojo. An experimental approach to study the binding properties of vitamin E (alpha-tocopherol) during hairless mouse skin permeation. Chem Pharm Bull, 49 (6): 659-663, 2001. |
2. |
森大輔, 東條角治. 経皮治療システム設計用体内動態シミュレ−ションソフトウェア・SKIN-CADtm. Pharm Tech Japan, 17 (5): 79-86, 2001. |
3. |
引間知広, 東條角治. 経皮治療システム研究における皮膚モデル. Drug Deliv Syst, 16 (3): 179-181, 2001. |
4. |
K. Tojo, A. Isowaki. Pharmacokinetic model for in vivo/in vitro correlation of intravitreal drug delivery. Adv Drug Deliv Rev, 51 (1): 17-24, 2001. |
5. |
東條角治. 水晶体ドラッグデリバリーシステムの眼科薬物動態. 日本白内障学会誌, 13: 5-12, 2001. |
6. |
K. Tojo. Development of smart drug delivery systems that learn from nature. KONA, 19: 16-24, 2001. |
1. |
H. Hamada, R. Sakiyama, A. C. Yamashita, M. Okamoto, K. J. Tojo. New Analytical Solution for Pyle-Popovich’s Peritoneal Dialysis Model. J Chem Eng Japan, 32 (4): 498-505, 1999. |
2. |
K. Tojo, K. Nakagawa, Y. Morita, A. Ohtori. A pharmacokinetic model of intravitreal delivery of ganciclovir. Eur J Pharm Biopharma, 47 (2): 99-104, 1999. |
3. |
東條角治. 貼る農薬製剤の開発と課題. 今月の農業, 43: 29-33, 1999. |
1. |
T. Hikima, Y. Hirai, K. Tojo. Effect of ultrasound application on the skin metabolism of prednisolone 21-acetate. Pharm Res, 15 (11): 1680-1683, 1998. |
2. |
青柳寿枝, 古川芳子, 磯脇明治, 東條角治. あたらしい眼科, 15(7): 1049-1052, 1998. |
3. |
K. Tojo, H. Aoyagi, T. Kurita. Surface dissolution-bulk erosion model of drug release from biodegradable polymer rods. J Chem Eng Japan, 31 (4):648-651, 1998. |
4. |
森田泰司, 斉野裕子, 東條角治. 眼深部組織へのドラッグデリバリーシステム. 日本臨牀, 56(3): 76(628)-79(631), 1998. |
5. |
Y. Morita, A. Ohtori, M. Kimura, K. Tojo. Intravitreous delivery of dexamethasone sodium m-sulfobenzoate from poly(DL-lactic acid) implants. Biol Pharm Bull, 21 (2): 188-190, 1998. |
6. |
Y. Morita, H. Saino, K. Tojo. Polymer blend implant for ocular delivery of fluorometholone. Biol Pharm Bull, 21 (1): 72-75, 1998. |
7. |
A. C. Yamashita, R. Sakiyama, H. Hamada, K. J. Tojo. Control of rate of solution transport in newly developed novel portable agar blood purification system, Home Homodialysis international, 2: 67-70, 1998. |
8. |
A. -R. Lee, K. Tojo. Characterization of skin permeation of vitamin C: theoretical analysis of penetration profiles and differential scanning calorimetry study. Chem Pharm Bull (Tokyo), 46 (1): 174-177, 1998. |
1. |
K. Yamada, K. Tojo. Bioconversion of estradiol esters in the skin of various animal models in vitro. Eur J Pharm Biopharm, 43 (3): 253-258, 1997. |
2. |
T. Hikima, K. Tojo. Binding of prednisolone and its ester prodrugs in the skin. Pharm Res, 14 (2): 197-202, 1997. |
3. |
K.Tojo, N. Hatae, K. Nakagawa, A. Yoshida. Adhesive systems for pesticide delivery through plant stems. Pestic Sci, 49: 35-39, 1997. |
1. |
A. R. Lee, K. Tojo. Evaluation for intrinsic skin permeation of unstable compounds. Chem Pharm Bull (Tokyo), 44 (8): 1621-1623, 1996. |
2. |
A. Yamashita, Y. Hirai, K. Tojo. Effect of ultrasound on rate of drug absorption throgh skin. J Chem Eng Japan, 29 (5):812-816, 1996. |
3. |
A. Yamashita, K. Tanaka, K. Tojo. Periodic Control of Rate of Drug Permeation through the Skin with Iontophoresis. J Chem Eng Japan, 29 (5):825-829, 1996. |
4. |
A. -R. C. Lee, K. Tojo. Metabolism of vitamin E during skin permeation. J Soc Cosmet Chem, 47: 85-95, 1996. |
4. |
宇野久美子, 中川勝憲, 東條角治. 硝子体およびその周辺組織への薬物ターゲティング. Drug Deliv Syst, 11 (2):133-, 1996. |
1. |
宇野久美子, 大鳥聡, 東條角治. 家兎硝子体内薬物挙動-In vitro硝子体膜透過実験-. あたらしい眼科, 11 (4): 別冊, 1994. |
2. |
K. Tojo, K. Yamada, T. Hikima. Diffusion and metabolism of prednisolone farnesylate in the stripped skin. Pharm Res, 11 (3): 393-397, 1994. |
3. |
A. Ohtori, K. Tojo. In vivo/in vitro correlation of intravitreal delivery of drugs with the help of computer simulation. Biol Pharm Bull, 17 (2): 283-290, 1994. |
4. |
A. C. Yamashita, K.J. Tojo, J. W. Moncrief. Influences of various experimental assumptions on measurements of peritoeal mass transfer rates. Artif Organs Today, 4: 117-127, 1994. |
5. |
A. Ohtori, K. Tojo. Pharmacokinetic model of intravitreal drug injection. Math Biosci, 123 (1): 59-75, 1994. |
1. |
東條角治. 眼圧降下剤チモロールの眼内移行. あたらしい眼科, 9 (8): 1398-1400, 1992. |
2. |
引間知広, 山田佳世子, 山下明泰, 東條角治. 代謝をともなう薬物の皮膚透過. Drug Deliv Syst, 7: 453-457, 1992. |
3. |
山下明泰, 引間知広, 大鳥聡, 東條角治. 薬物皮膚透過におよぼす温度の影響-in vitro実験による評価. Therapeutic Research, 13: 3129-3130, 1992. |