Achievements研究成果
最近の論文
- AI班
- Iwata, M., Kosai, K., Ono, Y., Oki, S., Mimori, K., and Yamanishi, Y.,
"Regulome-based characterization of drug activity across the human diseasome",
npj Systems Biology and Applications, 8:44, 2022.
- Nakamura, T., Iwata, M., Hamano, M., Eguchi, R., Takeshita, J., and Yamanishi, Y.,
"Small compound-based direct cell conversion with combinatorial optimization of pathway regulations",
Bioinformatics, 38:ii99-ii105, 2022.
- Eguchi, R., Hamano, M., Iwata, M., Nakamura, T., Oki, S., and Yamanishi, Y.,
"TRANSDIRE: data-driven direct reprogramming by a pioneer factor-guided trans-omics approach",
Bioinformatics, 38(10), 2839-2846, 2022.
- Kaitoh, K. and Yamanishi, Y.,
"Scaffold-Retained Structure Generator to Exhaustively Create Molecules in an Arbitrary Chemical Space",
Journal of Chemical Information and Modeling, 62(9), 2212–2225, 2022.
- Zou, Z., Iwata, M. Yamanishi, Y., and Oki, S.,
"Epigenetic landscape of drug responses revealed through large-scale ChIP-seq data analyses",
BMC Bioinformatics, 23:51, 2022.
- Kaitoh, K. and Yamanishi, Y.,
"TRIOMPHE: Transcriptome-based Inference and Generation of Molecules with Desired Phenotypes by Machine Learning",
Journal of Chemical Information and Modeling, 61(9), 4303–4320, 2021.
- Berenger, F. Kumar, A., Zhang, K. and Yamanishi, Y.,
"Lean-Docking: Exploiting Ligands’ Predicted Docking Scores to Accelerate Molecular Docking",
Journal of Chemical Information and Modeling, 24;61(5):2341-2352, 2021.
- Berenger, F. Kumar, A., Zhang, K. and Yamanishi, Y.,
"Lean-Docking: Exploiting Ligands’ Predicted Docking Scores to Accelerate Molecular Docking",
Journal of Chemical Information and Modeling, 24;61(5):2341-2352, 2021.
- Nishida, C., Tomonaga, T., Izumi, H., Wang, K.Y., Higashi, H., Ishidao, T., Takeshita, J.I., Ono, R., Sumiya, K., Fujii, S., Mochizuki, S., Sakurai, K., Yamasaki, K., Yatera, K., and Morimoto, Y.,
"Inflammogenic effect of polyacrylic acid in rat lung following intratracheal instillation",
Particle and Fibre Toxicology, 19:8, 2022
- Tanigaki, S., Takeshita, J.I., Itaka, S., and Suzuki, T.,
"Measurement precision with ordinal categorical data considering dose-response relationships",
Total Quality Science, 7(1), 31-41, 2022.
- Asai, T., Takeshita, J.I., Shimizu, Y., Tochikubo, Y., Shizu, R., Hosaka, T., Kanno, Y., and Yoshinari, K.,,
"Chemical characterization of anemia-inducing aniline-related substances and their application to the construction of a decision tree-based anemia prediction model",
Food and Chemical Toxicology, 157:112547, 2021.
- Shimizu, Y., Sasaki, T., Takeshita, J.I., Watanabe, M., Shizu, R., Hosaka, T., and Yoshinari, K.,
"Identification of average molecular weight (AMW) as a useful chemical descriptor to discriminate liver injury-inducing drugs",
PLoS ONE, 16(6):e0253855, 2021.
- Takeshita, J.I., Toyoda. A., Tani, H., Endo, Y., and Miyamoto, S.,
"Classification of chemical compounds based on the correlation between in vitro gene expression profiles",
Bulletin of Informatics and Cybernetics, 53(4), 1-14, 2021.
- Nonaka, H., Mino, T., Sakamoto, S., Oh, J. H., Watanabe, Y., Ishikawa, M., Tsushima, A., Amaike, K., Kiyonaka, S., Tamura, T., Aricescu, A. R., Kakegawa, W., Miura, E., Yuzaki, M., Hamachi, I.,
"Revisiting PFA-mediated tissue fixation chemistry: FixEL enables trapping of small molecules in the brain to visualize their distribution dynamics",
Chem, 9, 523–540, 2023.
- Ueda, A., Aihara, Y., Sato, S., Kano, K., Mishiro-Sato, E., Kitano, H., Sato, A., Fujimoto, K. J., Yanai, T., Amaike, K., Kinoshita, T., Itami K.,
"Discovery of 2,6-Dihalopurines as Stomata Opening Inhibitors: Implication of an LRX-mediated H+-ATPase Phosphorylation Pathway",
ACS Chemical Biology, 2023. DOI: 10.1021/acschembio.2c00771
- Ueda, A., Amaike, K., Shirotani, Y., Warstat, R., Ito, H., Choi, J.-H., Kawagishi, H., Itami, K.,
"C–H arylation enables synthesis of imidazole-4-carboxamide (ICA) based fairy chemicals with plant growth promoting activity",
Canadian Journal of Chemistry, 2023, DOI: 10.1139/cjc-2022-0256
- Fujiki, S., Amaike, K., Yagi, A., Itami, K.,,
"Synthesis, properties, and material hybridization of bare aromatic polymers enabled by dendrimer support",
Nature Communications, 13, 5358, 2022.
- Kolarski, D., Miller, S., Oshima, T., Nagai, Y., Aoki, Y., Kobauri, P., Srivastava, A., Sugiyama, A., Amaike, K., Sato, A., Tama, F., Szymanski, W., Feringa, B., Itami, K., Hirota, T.,
"Photopharmacological Manipulation of Mammalian CRY1 for Regulation of the Circadian Clock",
Journal of the American Chemical Society, 143, 2078–2087, 2021.
- 医療データ班
- Chuma, M., Hamano, H., Bando, T., Kondo, M., Okada, N., Izumi, Y., Ishida, S., Yoshioka, T., Asada, M., Niimura, T., Zamami, Y., Takechi, K., Goda, M., Miyata, K., Yagi, K., Kasamo, S., Izawa-Ishizawa, Y., Azuma, M., Yanagawa, H., Tasaki, Y. and Ishizawa, K.,
“Non-recovery of vancomycin-associated nephrotoxicity is related to worsening survival outcomes—combined retrospective analyses of two real-world databases”,
Basic & Clinical Pharmacology & Toxicology, 131, 525-535, 2022.
- Nawa, H., Hamano, H., Niimura, T., Miyata, K., Yagi, K., Goda, M., Zamami, Y. and Ishizawa, K.,
“Evaluation of the potential complication of interstitial lung disease associated with antifibrotic drugs using data from databases reporting spontaneous adverse effects”,
Clinical and Translational Science, 15(12), 2982-2988, 2022.
- Nishiuchi, S., Yagi, K., Saito, H., Zamami, Y., Niimura, T., Miyata, K., Sakamoto, Y., Fukunaga, K., Ishida, S., Hamano, H., Aizawa, F., Goda, M., Chuma, M., Izawa-Ishizawa, Y., Nawa, H., Yanagawa, H., Kanda, Y. and Ishizawa, K.,
“Investigation of drugs for the prevention of doxorubicin-induced cardiac events using big data analysis”,
European Journal of Pharmacology, 928, 175083, 2022.
- Zamami, Y., Niimura, T., Kawashiri, T., Goda, M., Naito, Y., Fukushima, K., Ushio, S., Aizawa, F., Hamano, H., Okada, N., Yagi, K., Takechi, K., Chuma, M., Koyama, T., Kobayashi, D., Shimazoe, T., Fujino, H., Izawa-Ishizawa, Y. and Ishizawa, K.,
"Identification of Prophylactic Drugs for Oxaliplatin-Induced Peripheral Neuropathy using Big Data",
Biomedicine & Pharmacotherapy, 148, 112744, 2022.
- Uchida, M., Ushio, S., Niimura, T., Takechi, K., Kawazoe, H., Hidaka, N., Tanaka, A., Araki, H., Zamami, Y., Ishizawa, K., Kitamura, Y., Sendou, T., Kawasaki, H., Namba, H., Shibata, K., Tanaka, M. and Takatori, S.,
"Renin-Angiotensin-Aldosterone System Inhibitors Prevent the Onset of Oxaliplatin-Induced Peripheral Neuropathy: A Retrospective Multicenter Study and in Vitro Evaluation",
Biological and Pharmaceutical Bulletin, 45(2), 226–234, 2022.
- Zamami, Y., Hamano, H., Niimura, T., Aizawa, F., Yagi, K., Goda, M., Izawa-Ishizawa, Y. and Ishizawa, K.,
"Drug-Repositioning Approaches Based on Medical and Life Science Databases",
Frontiers in Pharmacology, 12, 752174, 2021.
- Hamano, H., Ikeda, Y., Goda, M., Fukushima, K., Kishi, S., Chuma, M., Yamashita, M., Niimura, T., Takechi, K., Imanishi, M., Zamami, Y., Horinouchi, Y., Izawa-Ishizawa, Y., Miyamoto, L., Ishizawa, K., Fujino, H., Tamaki, T., Aihara, K. and Tsuchiya, K.,
"Diphenhydramine may be a preventive medicine against cisplatin-induced kidney toxicity",
Kidney international, 99, 885-899, 2021.
- Yagi, K., Mitstui, M., Zamami, Y., Niimura, T., Izawa-Ishizawa, Y., Goda, M., Chuma, M., Fukunaga, K., Shibata, T., Ishida, S., Sakurada, T., Okada, N., Hamano, H., Horinouchi, Y., Ikeda, Y., Yanagawa, H. and Ishizawa, K.,
"Investigation of drugs affecting hypertension in bevacizumab-treated patients and examination of the impact on the therapeutic effect",
Cancer Medicine, 10(1):164-172, 2021.
- 薬理班
- Niimura, T., Zamami, Y., Miyata, K., Mikami, Y., Asada, M., Fukushima, K., Yoshino, M., Mitsuboshi, S., Okada, N., Hamano, H., Sakurada, T., Matsuoka-Ando, R., Aizawa, F., Yagi, K., Goda, M., Chuma, M., Koyama, T., Izawa-Ishizawa, Y., Yanagawa, H., Fujino, H., Yamanishi, Y., Ishizawa, K.,
“Characterization of Immune Checkpoint Inhibitor–Induced Myasthenia Gravis Using the US Food and Drug Administration Adverse Event Reporting System”,
Journal of Clinical Pharmacology, in press.
- Ando-Matsuoka, R., Yagi, K., Takaoka, M., Sakajiri, Y., Shibata, T., Sawada, R., Maruo, A., Miyata, K., Aizawa, F., Hamano, H., Niimura, T., Izawa-Ishizawa, Y., Goda, M., Sakaguchi, S., Zamami, Y., Yamanishi, Y., Ishizawa, K.,
"Differential effects of proton pump inhibitors and vonoprazan on vascular endothelial growth factor expression in cancer cells”,
Drug Development Research, in press.
- Kanda, M., Goda, M., Maegawa, A., Yoshioka, T., Yoshida, A., Miyata, K., Aizawa, F., Niimura, T., Hamano, H., Okada, N., Sakurada, T., Chuma, M., Yagi, K., Izawa-Ishizawa, Y., Yanagawa, H., Zamami, Y., Ishizawa, K.,
"Discovery of preventive drugs for cisplatin-induced acute kidney injury using big data analysis”,
.Clinical and Translational Science, 15: 1664-1675, 2022.
- Sakurada, T., Nokihara, H., Koga, T., Zamami, Y., Goda, M., Yagi, K., Hamano, H., Aizawa, F., Ogino, H., Sato, S., Kirino, Y., Goto, H., Nishioka, Y. and Ishizawa, K.,
“Prevention of Pemetrexed-Induced Rash Using Low-Dose Corticosteroids: A Phase II Study”,
The Oncologist, 27(7):e554-e560, 2022.
- Chuma, M., Nakamoto, A., Bando, T., Niimura, T., Kondo, Y., Hamano, H., Okada, N., Asada, M., Zamami, Y., Takechi, K., Goda, M., Miyata, K., Yagi, K., Yoshioka, T., Izawa-Ishizawa, Y., Yanagawa, H., Tasaki, Y. and Ishizawa, K.,,
"Association between statin use and daptomycin-related musculoskeletal adverse events: A mixed approach combining a meta-analysis and a disproportionality analysis",
Clinical Infectious Diseases, ciac128, 2022..
- Okada, N., Izumi, Y., Nakamoto, A., Chuma, M., Goda, M., Yagi, K., Aizawa, F., Hamano, H., Zamami, Y., Azuma, M. and Ishizawa, K.,
"Impact of Area Under the Concentration–Time Curve on the Prevalence of Vancomycin-Induced Nephrotoxicity in Combination With Tazobactam/Piperacillin or Cefepime: A Single-Institution Retrospective Study",
Clinical Therapeutics, 44(6), 869–874, 2021.
- Goda, M., Kanda, M., Yoshioka, T., Yoshida, A., Murai, Y., Zamami, Y., Aizawa, F., Niimura, T., Hamano, H., Okada, N., Yagi, K., Chuma, M., Izawa-Ishizawa, Y. and Ishizawa, K.,
"Effects of 5-HT₃ receptor antagonists on cisplatin-induced kidney injury",
Clinical and Translational Science, 14(5):1906-1916, 2021.
- Takahashi, S., Takechi K., Jozukuri, N., Niimura, T., Chuma, M., Goda, M., Zamami, Y., Izawa-Ishizawa, Y., Imanishi, M., Horinouchi, Y., Ikeda, Y., Tsuchiya, K., Yanagawa, H. and Ishizawa, K.,
"Examination of the antiepileptic effects of valacyclovir using kindling mice― search for novel antiepileptic agents by drug repositioning using a large medical information database",
European Journal of Pharmacology, 902, 174099, 2021.
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