学術論文

北田が責任著者の論文を＊で示す。

  1. Okassov A., Nersesyan A.,Kitada S., and Irin A. Parasporins as new natural anticancer agents.Journal of BUON 20, 5-16, review (2015)
  2. Ekino K., Okumura O, Ishikawa T., Kitada S, Saitoh H., Akao T., Oka T., Nomura N., Ohba M., Shin S., Mizuki E. Cloning and characterization of a unique cytotoxic protein parasporin-5 produced by Bacillus thuringiensis A1100 strain. Toxins 6, 2115-2126 (2014)
  3. Shimada, H and *Kitada S. Mega Assemblages of Oligomeric Aerolysin-like Toxins Stabilized by Toxin-associating Membrane Proteins J.Biochem 149, 103-115 (2011)
  4. ;*Kitada, S., Yuichi Abe, Maeda, T., and Shimada H. Parasporin-2 requires GPI-anchored proteins for the efficient cytocidal action to human hepatoma cells.Toxicology. 264, 80-88 (2009).
  5. Akiba T., Abe Y., Kitada S., Kusaka Y., Ito A., Ichimatsu T., Katayama H., Akao T.,Higuchi K., Mizuki E., Ohba M., Kanai R., Harata K.. Crystal Structure of the Parasporin-2 Bacillus thuringiensis Toxin That Recognizes Cancer Cells. J. Mol. Biol. 386, 121-133 (2009)
  6. Tomohiro S., Kawaguti A., Kawabe Y., Kitada S., and Kuge O. Purification and characterization of human phosphatidylserine synthase 1 and 2. Biochem. J. 418, 421-429 (2009)
  7. *Abe, Y., Shimada, Y., and Kitada, S., Raft-targeting and Oligomerization of Parasporin-2, a Bacillus thuringiensis Crystal Protein with Anti-tumor Activity J. Biochem.143, 269-275 (2008).
  8. *Tomonori G. Nishino, T. G., Katsuhiko. K., Kojima, K., Ogishima, T., Ito, A., and Kitada, S. Spatial orientation of mitochondrial processing peptidase and a preprotein revealed by fluorescence resonance energy transfer J. Biochem. 141, 889-895 (2007).
  9. *Kitada, S., Uchiyama, T., Funatsu, T., Kitada, Y., Ogishima, T., and Ito, A.  A Protein from a Parasitic Microorganism, Rickettsia prowazekii, Can Cleave the Signal Sequences of Proteins Targeting Mitochondria. J Bacteriol. 189, 844-850 (2007).
  10. *Kitada, S., Abe, Y., Shimada, H., Kusaka, K., Matsuo, M., Katayama, H., Okumura, S., Akao, T., Mizuki, E., Kuge, O., Sasaguri, Y., Ohba, M., and Ito A. Cytocidal Actions of Parasporin-2, an Anti-tumor Crystal Toxin from Bacillus thuringiensis. J. Biol. Chem. 281, 26350-26360 (2006).
  11. *Oshima, T., Yamasaki, E., Ogishima, T., Kadowaki, K., Ito A., and Kitada S. Recognition and processing of a nuclear-encoded polyprotein precursor by mitochondrial processing peptidase. Biochem. J. 385, 755-761 (2005).
  12. Akiba, T., Abe, Y., Kitada, S., Kusaka, Y., Ito, A., Ichimatsu T., Katayama, H., Akao, T., Higuch, K., Mizuki E., Ohba M., Kanai R., and Harata K. Crystallization of parasporin-2, a Bacillus thuringiensis crystal protein with selective cytocidal activity against human cells.  Acta Cryst. D 60, 2355-2357. (2004)　
  13. Ito, A., Sasaguri, Y., Kitada, S., Kusaka, Y., Kuwano, K., Masutomi, K., Mizuki, E., Akao, T., Ohba, M. A Bacillus thuringiensis Crystal Protein with Selective Cytocidal Action to Human Cells. J. Biol. Chem. 279, 21282-21286. (2004). 
  14. *Kitada S., Yamasaki E., Kojima K., and Ito A. Determination of the Cleavage Site of the Presequence by Mitochondrial Processing Peptidase on the Substrate Binding Scaffold and the Multiple Subsite inside a Molecular Cavity. J. Biol. Chem. 278, 1879-1885. (2003)
  15. Kojima K., Yamasaki E., Kitada S., Ogishima T., and Ito A.  Recognition of mitochondrial protein precursor lacking arginine at position -2 by mitochondrial processing peptidase: processing of bovine cytochrome p450(scc) precursor. J. Biochem. 130, 497-502. (2001)  
  16. *Kitada S., Kojima K., and Ito A..  Glu191 and Asp195 in Rat Mitochondrial Processing Peptidase β Subunit Are Involved in Effective Cleavage of Precursor Protein through Interaction with the Proximal Arginine. Biochem. Biophys. Res. Commun.. 287, 594-599. (2001)
  17. Taylor A. B., Smith B. S., Kitada S., Kojima K., Miyaura H., Otwinowski Z., Ito A., and Deisenhofer J.  Crystal Structures of Mitochondrial Processing Peptidase Reveal the Mode for Specific Cleavage of Import Signal Sequences. Structure 9, 615-625. (2001)
  18. *Kitada S. and Ito A.  Electrostatic recognition of matrix targeting signal by mitochondrial processing peptidase. J. Biochem. 129, 155-161 (2001)   
  19. Kojima K., Kitada S., Ogishima T., and Ito A.  A proposed common structure of substrates bound to mitochondrial processing peptidase. J. Biol. Chem. 276, 2115-2121. (2001)　
  20. Suzuki H., Okazawa Y., Komiya T., Saeki K., Mekada E., Kitada S., Ito A., and Mihara K.  Characterization of rat TOM40, a central component of the preprotein translocase of the mitochondrial outer membrane. J. Biol. Chem. 275, 37930-37936. (2000)
  21. Nagao Y., Kitada S., Kojima K., Toh H., Kuhara S., Ogishima T., and Ito A.  Glycine-rich region of mitochondrial processing peptidase α-subunit is essential for binding and cleavage of the precursor proteins. J. Biol. Chem. 275, 34552-34556. (2000)
  22. Kitada S., Kojima K., Shimokata K., Ogishima T., and Ito A.  Glutamate residues required for substrate binding and cleavage activity in mitochondrial processing peptidase. J. Biol. Chem. 273, 32547-32553. (1998)       
  23. Kojima K., Kitada S., Shimokata K., Ogishima T., and Ito A.  Cooperative formation of a substrate binding pocket by α and β-subunits of mitochondrial processing peptidase. J. Biol. Chem. 273, 32542-32546. (1998) 
  24. Shimokata K., Kitada S., Ogishima T., and Ito A.  Role of α-subunit of mitochondrial processing peptidase in substrate recognition. J. Biol. Chem. 273, 25158-25163. (1998)
  25. Shimokata K., Nishio T., Song M.C., Kitada S., Ogishima T., and Ito A.  Substrate recognition by mitochondrial processing peptidase toward the malate dehydrogenase precursor. J. Biochem. 122, 1019-1023 (1997)
  26. Song M.C., Shimokata K., Kitada S., Ogishima T., and Ito  A. Role of basic amino acids in the cleavage of synthetic peptide substrates by mitochondrial processing peptidase. J. Biochem. 120, 1163-1166. (1996)
  27. Ogishima T., Niidome T., Shimokata K., Kitada S., and Ito A.  Analysis of elements in the substrate required for processing by mitochondrial processing peptidase. J. Biol. Chem. 270, 30322-30326. (1995)
  28. Kitada S., Shimokata K., Niidome T., Ogishima T., and Ito A.  A putative metal-binding site in the β subunit of rat mitochondrial processing peptidase is essential for its catalytic activity. J. Biochem. 117, 1148-1150. (1995)
  29. Niidome T., Kitada S., Shimokata K., Ogishima T., and Ito A.  Arginine residues in the extension peptide are required for cleavage of a precursor by mitochondrial processing peptidase. Demonstration using synthetic peptide as a substrate. J. Biol. Chem. 269, 24719-24722. (1994) 
  30. Ou W.J., Kumamoto T., Mihara K., Kitada S., Niidome T., Ito A., and Omura T.  Structural requirement for recognition of the precursor proteins by the mitochondrial processing peptidase. J. Biol. Chem. 269, 24673-24678. (1994) 
  31. Kitada S., Niidome T., Nagano T., Ogishima T., and Ito A.  Molecular cloning of the smaller subunit(P52) of rat liver mitochondrial processing protease. Biochem. Biophys. Res. Commun.. 190, 289-293. (1993) 

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