T. Matsui, Y. Higashimoto, J. Taira, and S. Yamagishi
Pigment epithelium-derived factor (PEDF) binds to caveolin-1 and inhibits the pro-inflammatory effects of caveolin-1 in
endothelial cells
Biochem. Biophys. Res. Commun
., 441, 405-410, 2013
Y. Higashimoto, T. Matsui, Y. Nishino, J. Taira, H. Inoue, M. Takeuchi, and S. Yamagishi
Blockade by phosphorothioate aptamers of advanced glycation end products-induced damage in cultured
pericytes and endothelial cells
Microvasc. Res.,
90, 64-70, 2013



J. Taira, T. Ito, H. Nakatani, T. Umei, H. Baba, S. Kawashima, T. Maruoka, H. Komatsu, H. Sakamoto, S. Aoki
In silico structure-based drug screening of novel antimycobacterial pharmacophores by DOCK-GOLD tandem screening
Int. J. Mycobacteriol., in press
J. Taira, Y. Kida, K. Kuwano, and Y. Higashimoto
Protein phosphatase 2A dephosphorylates phosphoserines in nucleocytoplasmic shuttling and
secretion of high mobility group box 1
J. Biochemistry
, 154, 299-308, 2013
Y. Ishibashi, T. Matsui, J. Taira, Y. Higashimoto, S. Yamagishi
Protective role of PEDF-derived synthetic peptide against experimental diabetic nephropathy
Horm. Metab. Res.
48, 613-619, 2016
H. Osako, J. Taira, Y. Higashimoto, H. Kodama, S. Osada
Peptide deformylase processable triazole-containing formyl peptide mimetics
Peptide Science 2015
, 159-162


J. Taira, S. Wada, Y. Fukushima, S. Sueda, H. Komatsu, Y. Higashimoto, H. Sakamoto
Surface plasmon resonance study on the interaction between the N-terminal region of heme oxygenase-2 and
NADPH-cytochrome P450 reductase
Peptide Science 2015, 157-158, 2016
Y. Kida, J. Taira, K. Kuwano
EprS, an autotransporter serine protease, plays an important role in various pathogenic phenotypes of Pseudomonas aeruginosa
Microbiology 162, 318-329, 2016
J. Taira, Y. Nakashima, S. Yoshihara, S. Koga, S. Sueda, H. Komatsu, Y. Higashimoto, T. Takahashi, N. Tanioka,
H. Shimizu, H. Morimatsu, H. Sakamoto
Improvement of heme oxygenase-1-based heme sensor for quantifying free heme in biological samples

Analytical Biochemistry
489, 50-52, 2015
T. Matsui, A. Ojima, Y. Higashimoto, J. Taira, K. Fukami, S. Yamagishi
Pigment epithelium‑derived factor inhibits caveolin‑induced interleukin‑8 gene expression and proliferation of human
prostate cancer cells

Oncology Letters
10, 2644-2648, 2015


J. Taira, and Y. Higashimoto
Evaluation of in vitro
phosphorylation properties of predicted kinase which phosphorylate serines in nuclear
localization signal 1 in high mobility group box 1
J. Pept. Sci.,
20, 613-617, 2014


Y. Kida, J. Taira, T. Yamamoto, Y. Higashimoto, and K. Kuwano
EprS, an autotransporter protein of Pseudomonas
aeruginosa, possessing serine protease activity induces inflammatory responses through protease-activated receptors
Cell. Microbiol.
, 15, 1168-1181, 2013
J. Taira, and Y. Higashimoto
Caveolin-1 Interacts with Protein Phosphatase 5 and Modulates Its Activity
in Prostate Cancer Cells
Biochem. Biophys. Res. Commun.
, 431, 724-728, 2013
Kinjo, T., Koseki, Y., Kobayashi, M., Yamada, A., Morita, K., Yamaguchi, K., Tsurusawa, R.,
Gulten, G., Komatsu, H., Sakamoto, H., Sacchettini, J. C., Kitamura, M., and Aoki, S.

Identification of Compounds with Potential Antibacterial Activity against Mycobacterium
through Structure-Based Drug Screening

J. Chem. Inf. Model 53, 1200-1213, 2013.
H. Kanetaka, Y. Koseki, J. Taira, T. Umei, H. Komatsu, H. Sakamoto, G. Gulten, J. C. Sacchettini,
M. Kitamura, S. Aoki
Discovery of InhA inhibitors with anti-mycobacterial activity through a matched molecular pair approach
Eur. J. Med. Chem
. 94, 378-85, 2015
R. Tanaka, Y. Seki, Y. Saito, S. Kamiya, M. Fujita, H. Okutsu, T. Iyoda, T. Takai, T. Owaki, H. Yajima, J. Taira,
R. Hayashi, H. Kodama, T. Matsunaga, F. Fukai
Tenascin-C-derived peptide TNIIIA2 highly enhances cell survival and PDGF-dependent cell proliferation through
potentiated and sustained activation of integrin α5β1
J. Biol. Chem.,
289, 17699-708, 2014
Koga, S., Yoshihara, S., Bando, H., Yamasaki, K., Higashimoto, Y., Noguchi, M., Sueda, S.,
Komatsu, H., and Sakamoto, H.
Development of a Heme Sensor Using Fluorescently Labeled Heme Oxygenase-1
Anal. Biochem. 433, 2-9, 2013
J. Taira, M. Sugishima, Y. Kida, E. Oda, M. Noguchi, and Y. Higashimoto
Identification of Essential Amino acid residues involved in the interaction of heme oxygenase-1 with caveolin-1. Peptide Science 2011, 35-38


J. Taira, H. Sakamoto, Y. Higashimoto
Effect of glycogen synthase kinase 3 on the complex forming between growth factor receptor bound protein 14 and
insulin receptor
Peptide Science 2014
, 187-190
J. Taira, and Y. Higashimoto
Phosphorylation of Grb14 BPS domain by GSK-3 correlates with complex forming of Grb14 and insulin receptor
J. Biochemistry,
155, 353-60, 2014

福岡県飯塚市川津680-4研究棟W703, W704

mail: sakakanbio.kyutech.ac.jp


管理人  吉村崇志

J. Taira, Y. Kida, K. Inatomi, H. Komatsu, Y, Higashimoto, H. Sakamoto
Phosphorylation of clustered serine residues in the N-terminus of BPS domain negatively regulates formati on of the complex
between human Grb14 and insulin receptor
The Journal of Biochemistry, in press
J. Taira, Y. Kida, and Y. Higashimoto
Protein phosphatase 2A in macrophage dephosphorylates phosphoserines involved in nucleocytoplasmic shuttling and
secretion of high mobility group box 1

Peptide Science 2012
, 191-194